Generally, yes, but with a few exceptions. Vinegar is a fantastic natural fabric softener and odor neutralizer. However, because it is an acid, using it in every single load over several years can potentially weaken the rubber seals and hoses in some front-loading washing machines. The Best Practice for using vinegar with laundry loads is to pour more that 1/2 cup per load in the softener compartment. Avoid using it in the same load as bleach (dangerous fumes) or on elastic-heavy items like gym wear or swimwear, as the acid can eventually break down the spandex fibers.