Yes and no—it depends on the sting. For jellyfish stings, vinegar is the “gold standard” first aid because the acetic acid neutralizes the stinging cells (nematocysts) before they can release more venom into your skin. However, for bee and wasp stings, vinegar is primarily used to soothe the itch and reduce swelling after the stinger is removed. It does not “neutralize” the venom, but its cooling, acidic nature provides fast relief for the skin’s irritation. For jellyfish, pour vinegar generously over the area for 30 seconds. For bee stings, apply a soaked cotton ball for 10–15 minutes.